The charge asymmetry of leptons from W-bosons and the Drell-Yan cross section of massive charged lepton pairs from gamma^*/Z-bosons produced in ppbar collisions are measured using 110 pb^-1 of collisions taken by the Collider Detector at Fermilab (CDF) during 1992-95. The W-asymmetry measurement provides a precise constraint of the slope of the quark distribution ratio d(x)/u(x), over the x range of 0.006 to 0.34. The Drell-Yan measurement spans the mass range of 11 to 500 GeV/c^2, and QCD calculations using recent parton distribution functions are in good agreement with it.