We report on the first observation of the bottom-charm mesons B_c through the decay mode B^+/-_c -> J/psi l^+/- nu in 1.8 TeV ppbar collisions using the CDF detector at the Fermilab Tevatron. A fit of background and signal contributions to the observed J/psi l mas distribution yielded 20.4^+_ -5.5 events from B_c mesons. A fit to the same distribution with background alone was rejected at the level of 4.8 standard deviations. We measured the B^+_c mass to be 6.40 +/- 0.39 +/- 0.13 GeV/c^2 and the B^+_c lifetime to be 0.46^+0.18_ -0.16(stat.) +/- 0.03(syst.) ps. The measured production cross section times branching ratio for B^__c -> J/psi l^+ nu relative to that for B^+ -> J/psi K^+ is 0.132^+0.041_ -0.037(stat.) +/- 0.031(syst.)^+0.032_ -0.020(lifetime).